Our study aims to identify sex-associated differences in stroke and major bleed rates for patients with intracranial atherosclerosis (IA) and transient ischemic attack (TIA) when treated with dual antiplatelet therapy (DAPT) for secondary stroke prevention. The potential impact of our study could support change for treatment guidelines for secondary stroke prevention in men and women with IA treated with DAPT. It is reasonable to suggest that sex differences influence pathophysiology of intracranial atherosclerosis, IA-associated adverse events, and outcomes of patients with IA in response to DAPT.
In this retrospective observational case-control study, we used electronic medical records provided by the University of Utah Health to gather data. We performed a retrospective chart review of approximately 375 patients, of those and identified 89 patients. We extracted data documenting sex, age, follow-up appointments for their DAPT initiation (no longer than six months from DAPT start date) and if patients had a recurrent stroke or major bleed. For raw demographic data, including age and sex, we will use descriptive statistics in the form of means, standard deviations, and percentages.
Overall, a difference in the number of outcomes between men and women was detected. Although we had a low frequency of outcomes, we did see that more women had recurrent stroke whereas men have more major bleeding events. Men, making up (n=50) 56% of the total patients, had six major bleeding events and four recurrent stroke or TIA. Women (n=39), when compared to men, had more recurrent strokes (n=6) and fewer major bleeding events (n=4).
We expected a difference in major bleed and stroke rates between men and women with intracranial atherosclerosis and treated with dual antiplatelet therapy for secondary stroke prevention. While we see a difference in raw data, we are unable to say if an actual difference. Our study highlights the need for more data in this area of DAPT in IA.Recommend0 recommendationsPublished in