Introduction: Epilepsy and pain are neurological disorders that are in a great need of treatment innovation. Our objective of this study was to evaluate the addition of galanin analogs to current seizure and pain therapy.
Methods: We assessed for supra-additive effects for several drug combination with NAX 810-2 on groups of CF-1 mice in 6hz seizure model, and the carrageenan pain assay model. We also performed quantitative polymerase chain reactions for the presence of inflammatory cytokines.
Results: In the mouse corneal kindling model (32 mA) Nax 810-2 drug combinations that may show interest to further study for supra-additive effects are levetiracetam, lamotrigine, clobazam, valproate, and topiramate. The carrageenan model also supports there may be supra-additive effects with levetiractem, gabapentin, and valproate.
Conclusion: This study added evidence to support data on galanin interactions with medications, and has helped add other medications that may have a potential synergistic effect that could be further studied in the future.Recommend0 recommendationsPublished in